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Phenotypes Associated with This Genotype
Genotype
MGI:3040301
Allelic
Composition
Dnmt3btm1Enl/Dnmt3btm1Enl
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3btm1Enl mutation (1 available); any Dnmt3b mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• between E11.5 and E13.5, homozygous embryos are somewhat underrepresented from expected (14% actual vs 25% expected); most live embryos recovered at E13.5 exhibit subcutaneous edema and liver atrophy
• homozygosity is lethal between E13.5 and E16.5 showing progressive necrosis; no homozygous newborn mice are found
• no viable homozygotes are recovered at birth

growth/size/body
• embryos are growth impaired

nervous system
• rostral neural tube closure defects are seen in homozygous embryos

cardiovascular system
• in homozygotes at E14.5 and E15.5, the ventricular septum is not closed completely
• some embryos show ectopic hemorrhage in the head region at E13.5
• hemorrhaging in the middle of the dorsal root ganglia and in the limb region is also observed (data not shown)

liver/biliary system

embryo
• embryos are growth impaired
• rostral neural tube closure defects are seen in homozygous embryos


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory