Phenotypes Associated with This Genotype

Genotype
MGI:3040289

• Allelic Composition: Hr^rh-bmh/Hr^rh-bmh
• Genetic Background: involves: C57BL/6JRj * CBA/JRj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:89321 )

N • unlike other alleles of this gene, no defects in the thymus or in T cell development were detected

integument

dermal cyst ( J:89321 )

• deep dermal cysts and utricles appearing in a regular pattern

alopecia ( J:89321 )

• progressive loss of pelage hair beginning at two weeks after birth and complete loss by 4 weeks of age

abnormal hair follicle morphology ( J:89321 )

dilated hair follicle infundibulum ( J:89321 )

• high number of hair follicles with abnormally dilated infundibuli at 13-15 days of age

abnormal hair follicle inner root sheath morphology ( J:89321 )

• regressing inner root sheaths at 1 month of age

abnormal hair follicle outer root sheath morphology ( J:89321 )

• regressing outer root sheaths at 1 month of age

dilated piliary canal ( J:89321 )

• at 1 month of age, most hair follicles show dilated pilary canals filled with laminated cornified material

growth/size/body

dermal cyst ( J:89321 )

• deep dermal cysts and utricles appearing in a regular pattern