Phenotypes for Cxcl12 MGI:3040183 MGI Mouse

abnormal skin vasculature morphology ( J:195048 )

• mice exhibit a failure of nerve-vessel alignment in developing limb skin compared with wild-type mice

• however, vascular density is normal

lethality throughout fetal growth and development, incomplete penetrance ( J:34750 )

• about half of the homozygous embryos die between E15.5 and E18.5

neonatal lethality, complete penetrance ( J:34750 )

• homozygotes die within 1 hour of birth

abnormal skin vasculature morphology ( J:195048 )

• mice exhibit a failure of nerve-vessel alignment in developing limb skin compared with wild-type mice

• however, vascular density is normal

abnormal angiogenesis ( J:69256 )

• the large vessels of the stomach arising from the mesenchymal vessels are absent

• the small vascular network that surrounds the stomach and the vasculature of other organs are normal

poor arterial differentiation ( J:195048 )

abnormal developmental vascular remodeling ( J:195048 )

• disorganized branching patterns in developing limb skin

abnormal vascular smooth muscle morphology ( J:195048 )

• reduced smooth muscle cell coverage of small diameter branched vessels

• however, coverage of large diameter veins is normal

perimembraneous ventricular septal defect ( J:34750 )

• homozygotes have a defect in the membranous portion of the ventricular septum

decreased pro-B cell number ( J:34750 )

• pro-B cell numbers are severely reduced in the fetal livers of mutants compared to wild-type mice

impaired myelopoiesis ( J:49070 )

• at E18.5 in the fetal liver, myelopoiesis is reduced identical to the phenotype in Cxcr4^tm1Qma homozygotes

• at E18.5, a marked reduction in myeloid cells is also seen in the spleen and myeloid cells are virtually absent from the bone marrow

decreased bone marrow cell number ( J:34750 , J:49070 )

• on E17.5 hematopoietic cells are virtually absent from the bone marrow (J:34750)

• B-cell lymphopoiesis is also absent in the bone marrow (J:34750)

• at E18.5, myeloid cells are virtually absent from the bone marrow (J:49070)

decreased pre-B cell number ( J:34750 )

• by E16.5 pre-B cell numbers are severely reduced in the fetal livers of mutants compared to wild-type mice

nervous system phenotype ( J:195048 )

N	• mice exhibit normal innervation accompanied by migrating Schwann cells

abnormal cerebellum morphology ( J:49070 )

• at E18.5, the cerebellum is disorganized

thin external granule cell layer ( J:49070 )

• at E18.5, the external granule cell layer is attenuated