Phenotypes Associated with This Genotype

Genotype
MGI:3040174

• Allelic Composition: Rasa1^tm1Paw/Rasa1^tm1Paw
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:29825 )

• at E8.5 when embryo turning occurs, embryos were normal

• embryos were visibly abnormal by E9.25 and died by E10.5

cellular

abnormal cell death ( J:29825 )

• localized regions of cell death by E9.0 in the first branchial arch, hindbrain, optic stalk and telencephalon

embryo

abnormal developmental patterning ( J:29825 )

abnormal rostral-caudal axis patterning ( J:29825 )

• defect in posterior elongation by E9.25

embryonic growth arrest ( J:29825 )

• development is arrested by E9.5

decreased embryo size ( J:29825 )

• by E9.5, embryos were significantly smaller than normal littermates

abnormal embryonic tissue morphology ( J:29825 )

abnormal first pharyngeal arch morphology ( J:29825 )

• apoptotic cells in the neural crest of the first branchial arch

incomplete somite formation ( J:29825 )

• fewer than 25 somites at E9.5

excessive folding of visceral yolk sac ( J:29825 )

• yolk sac had an abnormal roughened or wrinkled appearance by E9.5

growth/size/body

decreased embryo size ( J:29825 )

• by E9.5, embryos were significantly smaller than normal littermates

craniofacial

abnormal first pharyngeal arch morphology ( J:29825 )

• apoptotic cells in the neural crest of the first branchial arch