Phenotypes Associated with This Genotype

Genotype
MGI:3039719

• Allelic Composition: Card11^tm1Litt/Card11^tm1Litt
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell proliferation ( J:89322 )

• B cells exhibited defects in activation; proliferation was reduced in response to stimulators

abnormal T cell differentiation ( J:89322 )

• premature maturation of DN thymocytes which then undergo a high rate of apoptosis

abnormal double-negative T cell morphology ( J:89322 )

• reduced proportion of DN3 T cells (CD4-, CD8-, CD25+, CD44lo)

• increased proportion of DN4 T cells (CD4-, CD8-, CD25-, CD44lo)

absent B-1a cells ( J:89322 )

• CD5+, B220+ B cells absent in peritoneum, although B lymphocyte development in the bone marrow was normal

decreased immunoglobulin level ( J:89322 )

• reduced basal serum immunoglobulin levels, including IgM, IgG1, IgG2b, IgG3, and IgA

decreased IgA level ( J:89322 )

decreased IgG1 level ( J:89322 )

decreased IgG2b level ( J:89322 )

decreased IgG3 level ( J:89322 )

decreased IgM level ( J:89322 )

abnormal T cell activation ( J:89322 )

abnormal T cell proliferation ( J:89322 )

• impaired proliferative response of T cells in response to anti-CD3 antibody

immune system

abnormal B cell proliferation ( J:89322 )

• B cells exhibited defects in activation; proliferation was reduced in response to stimulators

abnormal T cell differentiation ( J:89322 )

• premature maturation of DN thymocytes which then undergo a high rate of apoptosis

abnormal double-negative T cell morphology ( J:89322 )

• reduced proportion of DN3 T cells (CD4-, CD8-, CD25+, CD44lo)

• increased proportion of DN4 T cells (CD4-, CD8-, CD25-, CD44lo)

absent B-1a cells ( J:89322 )

• CD5+, B220+ B cells absent in peritoneum, although B lymphocyte development in the bone marrow was normal

decreased immunoglobulin level ( J:89322 )

• reduced basal serum immunoglobulin levels, including IgM, IgG1, IgG2b, IgG3, and IgA

decreased IgA level ( J:89322 )

decreased IgG1 level ( J:89322 )

decreased IgG2b level ( J:89322 )

decreased IgG3 level ( J:89322 )

decreased IgM level ( J:89322 )

abnormal T cell activation ( J:89322 )

abnormal T cell proliferation ( J:89322 )

• impaired proliferative response of T cells in response to anti-CD3 antibody

cellular

abnormal B cell proliferation ( J:89322 )

• B cells exhibited defects in activation; proliferation was reduced in response to stimulators

abnormal T cell proliferation ( J:89322 )

• impaired proliferative response of T cells in response to anti-CD3 antibody