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Phenotypes Associated with This Genotype
Genotype
MGI:3039428
Allelic
Composition
Selltm1Flv/Selltm1Flv
Genetic
Background
involves: C57BL/6 * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selltm1Flv mutation (0 available); any Sell mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• inflammation of the islet of Langerhans is seen by 9 weeks in mutant and wild-type mice

immune system
• inflammation of the islet of Langerhans is seen by 9 weeks in mutant and wild-type mice
• adoptive transfer experiment results with mutants backcrossed to NOD for 10 or more generations indicate that this reduction is a result of incomplete NOD genetic background
• the incidence of diabetes in these mutants is also decreased as a result of incomplete NOD genetic background

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:88974


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory