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Phenotypes Associated with This Genotype
Genotype
MGI:3039428
Allelic
Composition
Selltm1Flv/Selltm1Flv
Genetic
Background
involves: C57BL/6 * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selltm1Flv mutation (0 available); any Sell mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• inflammation of the islet of Langerhans is seen by 9 weeks in mutant and wild-type mice

immune system
• inflammation of the islet of Langerhans is seen by 9 weeks in mutant and wild-type mice
• adoptive transfer experiment results with mutants backcrossed to NOD for 10 or more generations indicate that this reduction is a result of incomplete NOD genetic background
• the incidence of diabetes in these mutants is also decreased as a result of incomplete NOD genetic background

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:88974


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory