Phenotypes Associated with This Genotype

Genotype
MGI:3039425

• Allelic Composition: Sell^tm1Flv/Sell^tm1Flv
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased activated T cell number ( J:89253 )

• following subcutaneous immunization with keyhole limpet hemocyanin/complete Freund's adjuvant (KLH/CFA) emulsion the number of lymphocytes from draining lymph nodes is significantly decreased compared to wild-type controls

• 5 days after immunization keyhole limpet hemocyanin-specific T-cell proliferative response in draining lymph nodes is dramatically decreased

• 9 days after immunization keyhole limpet hemocyanin-specific T-cell proliferative response in draining lymph nodes is restored to that in wild-type controls

abnormal type IV hypersensitivity reaction ( J:89253 )

• 4 days after KLH/CFA immunization the delayed type hypersensitivity responses are dramatically reduced in mutants compared to wild-type mice as a result of deficient T cell priming

hematopoietic system

decreased activated T cell number ( J:89253 )

• following subcutaneous immunization with keyhole limpet hemocyanin/complete Freund's adjuvant (KLH/CFA) emulsion the number of lymphocytes from draining lymph nodes is significantly decreased compared to wild-type controls

• 5 days after immunization keyhole limpet hemocyanin-specific T-cell proliferative response in draining lymph nodes is dramatically decreased

• 9 days after immunization keyhole limpet hemocyanin-specific T-cell proliferative response in draining lymph nodes is restored to that in wild-type controls