Phenotypes Associated with This Genotype

Genotype
MGI:3039402

• Allelic Composition: Foxo3^{Gt(VICTR20)1Kca}/Foxo3^{Gt(VICTR20)1Kca}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

early reproductive senescence ( J:88638 )

• females are infertile by the age of 10 weeks

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:88638 )

♀ • at 4.5 weeks mature follicles are much less common then in wild-type mice

impaired ovarian folliculogenesis ( J:88638 )

♀ • at 4.5 weeks growing follicles are prominent but mature follicles are much less common then in wild-type mice

♀ • at 12 weeks no developing follicles are present

reproductive system

oocyte degeneration ( J:88638 )

♀ • at 9.5 weeks many oocytes have undergone degeneration indicating initiation of atretic change

♀ • at 12 weeks all oocytes present have undergone degeneration

decreased mature ovarian follicle number ( J:88638 )

♀ • at 4.5 weeks mature follicles are much less common then in wild-type mice

impaired ovarian folliculogenesis ( J:88638 )

♀ • at 4.5 weeks growing follicles are prominent but mature follicles are much less common then in wild-type mice

♀ • at 12 weeks no developing follicles are present

early reproductive senescence ( J:88638 )

• females are infertile by the age of 10 weeks

cellular

oocyte degeneration ( J:88638 )

♀ • at 9.5 weeks many oocytes have undergone degeneration indicating initiation of atretic change

♀ • at 12 weeks all oocytes present have undergone degeneration