Phenotypes Associated with This Genotype

Genotype
MGI:3038842

• Allelic Composition: Cd93^tm1Mbo/Cd93^tm1Mbo
• Genetic Background: either: 129/Sv or B6.129-Cd93^tm1Mbo or (involves: 129/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired macrophage phagocytosis ( J:88610 )

• phagocytosis of apoptotic cells by, but not recruitment of, thioglycolate stimulated peritoneal macrophages is impaired in mutants compared to wild-type mice

• phagocytosis of coated red blood cells by thioglycolate stimulated peritoneal macrophages is unaffected

• leukocyte migration is not different in mutants compared to wild-type mice

hematopoietic system

impaired macrophage phagocytosis ( J:88610 )

• phagocytosis of apoptotic cells by, but not recruitment of, thioglycolate stimulated peritoneal macrophages is impaired in mutants compared to wild-type mice

• phagocytosis of coated red blood cells by thioglycolate stimulated peritoneal macrophages is unaffected

• leukocyte migration is not different in mutants compared to wild-type mice

cellular

impaired macrophage phagocytosis ( J:88610 )

• phagocytosis of apoptotic cells by, but not recruitment of, thioglycolate stimulated peritoneal macrophages is impaired in mutants compared to wild-type mice

• phagocytosis of coated red blood cells by thioglycolate stimulated peritoneal macrophages is unaffected

• leukocyte migration is not different in mutants compared to wild-type mice