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Phenotypes Associated with This Genotype
Genotype
MGI:3038633
Allelic
Composition
Gad2tm1Miya/Gad2tm1Miya
Genetic
Background
NOD.129P2-Gad2tm1Miya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad2tm1Miya mutation (0 available); any Gad2 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• between 16 and 32 weeks some mutants (7 out of 31) die suddenly from non-diabetic causes most likely related to seizures

behavior/neurological
• seizures induced by mild stimulation are seen in mutants

endocrine/exocrine glands
• no difference in the progression of insulitis (infiltration of the islet of Langerhans) is seen between mutants and wild-types by 12 weeks

growth/size/body
• after 4 weeks mild growth retardation is seen in mutants

homeostasis/metabolism
• no difference in incidence of diabetes is seen between female mutants and wild-types

immune system
• no difference in the progression of insulitis (infiltration of the islet of Langerhans) is seen between mutants and wild-types by 12 weeks

nervous system
• seizures induced by mild stimulation are seen in mutants

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
OMIM:300136
J:88785


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory