Phenotypes Associated with This Genotype

Genotype
MGI:3038308

• Allelic Composition: Il13^tm2Anjm/Il13^tm2Anjm
• Genetic Background: C.129P2(B6)-Il13^tm2Anjm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal type I hypersensitivity reaction ( J:123772 )

• neutralizing IL14 reduces response in sensitized mice down to that in unsensitized mice, unlike in wild-type mice

• neutralizing IL15 also reduces response in sensitized mutant mice but not in wild-type mice

increased susceptibility to type I hypersensitivity reaction ( J:123772 )

• show a heightened response relative to wild-type mice in a model of airways hyperreactivity (sensitized and aeroallergen challenged with OVA followed by challenge with Beta-metacholine)

• however, mucus hypersecretion in this model of airways hyperreactivity is reduced

abnormal response to transplant ( J:110188 )

• decrease in luminal occlusion in tracheal allografts from C57BL/6 mice compared to transplants into wild-type mice

• allografts do not show a significant upregulation of TGFB1 compared to isografts

increased length of allograft survival ( J:110188 )

• tracheal allografts from C57BL/6 mice display prolonged maintenance of epithelial integrity and absence of luminal fibroproliferation

homeostasis/metabolism

decreased susceptibility to injury ( J:88681 )

• decreased pulmonary fibrosis is seen after FITC treatment most likely a result of an overall decrease in collagen production