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Phenotypes Associated with This Genotype
Genotype
MGI:3038219
Allelic
Composition
GckRgsc392/GckRgsc392
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GckRgsc392 mutation (1 available); any Gck mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• growth retardation is not as severe as in Gck1Rgsc and Gck6Rgsc

homeostasis/metabolism
• hyperglycemia is detected by P2
• blood glucose levels reach 500 mg/dl and remain this high for at least 3 weeks after birth
• histological analysis reveals reduced liver glycogen levels

liver/biliary system
• histological analysis reveals increased numbers of fat droplets in hepatocytes however the gross appearance on the liver does not differ from wild-type

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:88919


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory