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Phenotypes Associated with This Genotype
Genotype
MGI:3037661
Allelic
Composition
Gy/Y
Genetic
Background
involves: C3H/Sn * C57BL/6Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (1 available); any Gy mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• a significant increase in lean body mass is seen compared to control

growth/size/body
• all males have significantly lower body weights (~50% less than controls) and a squared trunk
• male Gy mutants weigh significantly less than other PhexHyp male mutants (PhexHyp, PhexHyp-2J, PhexHyp-Duk)

hearing/vestibular/ear
• mean auditory brainstem response thresholds are significantly higher than controls

homeostasis/metabolism
• at 6 weeks of age serum Ca2+ are significantly decreased compared to controls
• at 6 weeks of age serum PO4 levels are significantly lower than controls

limbs/digits/tail
• shortened hind limbs are seen
• the fibula is shortened and splayed
• the tibia is shortened and splayed
• growth plates of the knee are thickened and irregular

skeleton
• growth plates of the knee are thickened and irregular
• disorganized femoral growth plates
• the long bones are shortened
• the fibula is shortened and splayed
• the tibia is shortened and splayed
• the long bones are thickened
• between 6 and 40 weeks of age under-mineralized bone is present throughout the body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
X-linked dominant hypophosphatemic rickets DOID:0050445 OMIM:307800
J:38621 , J:88352


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory