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Phenotypes Associated with This Genotype
Genotype
MGI:3037342
Allelic
Composition
Sftpctm1Swg/Sftpctm1Swg
Genetic
Background
either: 129/Sv or (involves: 129/Sv * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sftpctm1Swg mutation (0 available); any Sftpc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Airspace remodeling, stromal thickening and monocytic infiltration in the lungs of Sftpctm1Swg/Sftpctm1Swg mice

mortality/aging
• fecundity was reduced by 2 months of age (J:82925)
• very few litters were produced after 6 months of age (J:82925)
• fecundity was reduced by 2 months of age (J:82925)
• very few litters were produced after 6 months of age (J:82925)

behavior/neurological
• deteriorating coat condition after 2 months of age (J:82925)
• deteriorating coat condition after 2 months of age (J:82925)

growth/size/body
• 24% reduction in body weight by 1 year of age (J:82925)
• 24% reduction in body weight by 1 year of age (J:82925)

immune system

reproductive system
• fecundity was reduced by 2 months of age (J:82925)
• very few litters were produced after 6 months of age (J:82925)
• fecundity was reduced by 2 months of age (J:82925)
• very few litters were produced after 6 months of age (J:82925)

respiratory system
• alveolar capillary walls are thickened or obliterated by surrounding stroma and collagen (J:82925)
• alveolar capillary walls are thickened or obliterated by surrounding stroma and collagen (J:82925)
• epithelial cell dysplasia present by 6-12 months (J:82925)
• non ciliated columnar epithelia found with characteristics of Clara cells (J:82925)
• epithelial cell dysplasia present by 6-12 months (J:82925)
• non ciliated columnar epithelia found with characteristics of Clara cells (J:82925)
• interstitial thickening of the lung parenchyma (J:82925)
• perivascular and peribronchiolar monocyte infiltration in severely affected individuals (J:82925)
• interstitial thickening of the lung parenchyma (J:82925)
• perivascular and peribronchiolar monocyte infiltration in severely affected individuals (J:82925)
• enlarged by 2 months (J:82925)
• irregular alveolar septation and shortened septal tips (J:82925)
• loss of alveolar elastin fibers (J:82925)
• fibrosis and collagen deposition at thickened alveolar septal structures (J:82925)
• some alveolar spaces obliterated by 12 months of age (J:82925)
• enlarged by 2 months (J:82925)
• irregular alveolar septation and shortened septal tips (J:82925)
• loss of alveolar elastin fibers (J:82925)
• fibrosis and collagen deposition at thickened alveolar septal structures (J:82925)
• some alveolar spaces obliterated by 12 months of age (J:82925)
• excessive lamellar bodies in type II cells (J:82925)
• excessive lamellar bodies in type II cells (J:82925)
• hyperplasia of type II cells (J:82925)
• hyperplasia of type II cells (J:82925)
• enlarged by 2 months (J:82925)
• enlarged by 2 months (J:82925)
• irregular alveolar septation and shortened septal tips (J:82925)
• fibrosis and collagen deposition at thickened alveolar septal structures (J:82925)
• irregular alveolar septation and shortened septal tips (J:82925)
• fibrosis and collagen deposition at thickened alveolar septal structures (J:82925)
• regions of severe emphysema with septal thinning and degeneration of pulmonary capillaries (J:82925)
• regions of severe emphysema with septal thinning and degeneration of pulmonary capillaries (J:82925)
• loss of alveolar elastin fibers (J:82925)
• loss of alveolar elastin fibers (J:82925)
• airway resistance is increased (J:82925)
• airway resistance is increased (J:82925)

vision/eye

cardiovascular system
• alveolar capillary walls are thickened or obliterated by surrounding stroma and collagen (J:82925)
• alveolar capillary walls are thickened or obliterated by surrounding stroma and collagen (J:82925)

Mouse Models of Human Disease
OMIM ID Ref(s)
Interstitial Pneumonitis, Desquamative, Familial; DIP 263000 J:82925


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory