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Phenotypes Associated with This Genotype
Genotype
MGI:3037334
Allelic
Composition
Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic
Background
B6.Cg-Zfp36tm1Pjb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp36tm1Pjb mutation (1 available); any Zfp36 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increase in pro-inflammatory and atherosclerosis marker gene expression in aortas indicating vascular inflammation
• slight enhancement in the blood
• slight enhancement in the blood
• decrease in lymphocyte cell numbers
• slight enhancement in the blood
• in macrophages from double homozygotes lipopolysaccharide-induced expression of TNF- alpha is significantly increased
• homozygotes develop severe arthritis
• finger joints from double homozygotes display inflammatory pannus and bony erosions

skeleton
• homozygotes develop severe arthritis
• finger joints from double homozygotes display inflammatory pannus and bony erosions

hematopoietic system
• slight enhancement in the blood
• slight enhancement in the blood
• slight enhancement in the blood
• decrease in lymphocyte cell numbers
• slight enhancement in the blood
• in macrophages from double homozygotes lipopolysaccharide-induced expression of TNF- alpha is significantly increased

cardiovascular system
• aortas are less responsive to acetylcholine-induced relaxation mice however show similar relaxation responses to the NOS inhibitor L-NAME and to the NO-donor sodium nitroprusside
• increase in pro-inflammatory and atherosclerosis marker gene expression in aortas indicating vascular inflammation
• reduction in blood pressure

cellular
• mice show higher reactive oxygen and nitrogen species (RONS) formation in the presence of NADPH in cardiac membrane fractions, indicating enhanced burden of oxidative stress
• mice show higher reactive oxygen and nitrogen species (RONS) formation under PDBu-stimulated conditions in whole blood, indicating enhanced burden of oxidative stress

homeostasis/metabolism
N
• mice show normal blood cholesterol, triglyceride and glucose levels
• marker analysis indicates reduced NO bioavailability

muscle
• aortas are less responsive to acetylcholine-induced relaxation mice however show similar relaxation responses to the NOS inhibitor L-NAME and to the NO-donor sodium nitroprusside

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
rheumatoid arthritis DOID:7148 OMIM:180300
J:214114


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory