Phenotypes Associated with This Genotype

Genotype
MGI:3037267

• Allelic Composition: Pou2f2^tm1Bal/Pou2f2^tm1Bal
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:88240 )

• homozygous mice die shortly after birth

hematopoietic system

arrested B cell differentiation ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants peripheral B cells appear immature with high heat stable antigen levels

decreased B cell number ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants the proportion of B cells is significantly reduced

decreased immunoglobulin level ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants an 8 - 10 fold reduction in immunoglobulin concentrations is seen

immune system

arrested B cell differentiation ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants peripheral B cells appear immature with high heat stable antigen levels

decreased B cell number ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants the proportion of B cells is significantly reduced

decreased immunoglobulin level ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants an 8 - 10 fold reduction in immunoglobulin concentrations is seen