Phenotypes for Sim1 Sim2 MGI:3036853 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sim1^tm1Fan/Sim1⁺ Sim2^tm1Fan/Sim2⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1^tm1Fan mutation (0 available); any Sim1 mutation (52 available)
Sim2^tm1Fan mutation (0 available); any Sim2 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased susceptibility to weight gain ( J:76787 )

• after 7 months the average weight was identical to that of mice heterozygous only for Sim1^tm1Fan

nervous system

abnormal diencephalon morphology ( J:76787 )

• paraventricular nucleus and supraoptic nuclei are hypocellular

• the phenotype is identical to that of mice heterozygous only for Sim1^tm1Fan

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:76787

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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