Phenotypes Associated with This Genotype

Genotype
MGI:3036848

• Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr; Tg(TcraTcrb)425Cbn/?
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:88515 )

• CD4 thymocyte positive selection is impaired; mutants generate about 75% fewer CD4⁺ single-positive thymocytes than wild-type

decreased CD4-positive, alpha-beta T cell number ( J:88515 )

• mutants generate about 75% fewer CD4⁺ single-positive thymocytes than wild-type

abnormal splenic cell ratio ( J:88515 )

• decrease in splenic CD4:CD8 ratio

immune system

abnormal positive T cell selection ( J:88515 )

• CD4 thymocyte positive selection is impaired; mutants generate about 75% fewer CD4⁺ single-positive thymocytes than wild-type

decreased CD4-positive, alpha-beta T cell number ( J:88515 )

• mutants generate about 75% fewer CD4⁺ single-positive thymocytes than wild-type

abnormal splenic cell ratio ( J:88515 )

• decrease in splenic CD4:CD8 ratio