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Phenotypes Associated with This Genotype
Genotype
MGI:3036466
Allelic
Composition
Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13btm1Msc mutation (1 available); any Tnfsf13b mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• apparently at the T1 to T2 transition in splenic B cells (CD21 lo, IgMhi)
• apparently at the B1 to B2 transition in cells recovered from peritoneal lavage (B220+, CD23lo)
• severe losses of B220+ cells in secondary lymphoid tissue
• fewer follicular B cells than controls in spleen
• spleens had significantly fewer B cells in the marginal zone than in controls
• necropsy at 6 - 8 months of age showed significantly reduced average spleen weights
• 10-fold decrease in baseline total serum immunoglobulin concentration
• all Ig subclasses significantly reduced at baseline, with the exception of IgA, which was moderately reduced
• decreased immunoglobulin production after both T-dependent and T-independent immunization

immune system
• apparently at the T1 to T2 transition in splenic B cells (CD21 lo, IgMhi)
• apparently at the B1 to B2 transition in cells recovered from peritoneal lavage (B220+, CD23lo)
• severe losses of B220+ cells in secondary lymphoid tissue
• fewer follicular B cells than controls in spleen
• spleens had significantly fewer B cells in the marginal zone than in controls
• necropsy at 6 - 8 months of age showed significantly reduced average spleen weights
• abnormal B cell domain, with ~10-fold reduction in B cell numbers
• decreased immunoglobulin production after both T-dependent and T-independent immunization
• 10-fold decrease in baseline total serum immunoglobulin concentration
• all Ig subclasses significantly reduced at baseline, with the exception of IgA, which was moderately reduced
• decreased immunoglobulin production after both T-dependent and T-independent immunization


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory