hematopoietic system
• apparently at the T1 to T2 transition in splenic B cells (CD21 lo, IgMhi)
• apparently at the B1 to B2 transition in cells recovered from peritoneal lavage (B220+, CD23lo)
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• severe losses of B220+ cells in secondary lymphoid tissue
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• fewer follicular B cells than controls in spleen
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• spleens had significantly fewer B cells in the marginal zone than in controls
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• necropsy at 6 - 8 months of age showed significantly reduced average spleen weights
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• 10-fold decrease in baseline total serum immunoglobulin concentration
• all Ig subclasses significantly reduced at baseline, with the exception of IgA, which was moderately reduced
• decreased immunoglobulin production after both T-dependent and T-independent immunization
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immune system
• apparently at the T1 to T2 transition in splenic B cells (CD21 lo, IgMhi)
• apparently at the B1 to B2 transition in cells recovered from peritoneal lavage (B220+, CD23lo)
|
• severe losses of B220+ cells in secondary lymphoid tissue
|
• fewer follicular B cells than controls in spleen
|
• spleens had significantly fewer B cells in the marginal zone than in controls
|
• necropsy at 6 - 8 months of age showed significantly reduced average spleen weights
|
• abnormal B cell domain, with ~10-fold reduction in B cell numbers
|
• decreased immunoglobulin production after both T-dependent and T-independent immunization
|
• 10-fold decrease in baseline total serum immunoglobulin concentration
• all Ig subclasses significantly reduced at baseline, with the exception of IgA, which was moderately reduced
• decreased immunoglobulin production after both T-dependent and T-independent immunization
|