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Phenotypes Associated with This Genotype
Genotype
MGI:3036310
Allelic
Composition
Ddb2tm1Linn/Ddb2tm1Linn
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddb2tm1Linn mutation (0 available); any Ddb2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Tumorigenesis analysis and Hisptopathological images

tumorigenesis
• skin tumorigenesis is enhanced after exposure to UV light but not after exposure to DMBA (J:88125)
• tumors develop earlier, proceed at a greater rate and mice develop more tumors (J:88125)
• skin tumorigenesis is enhanced after exposure to UV light but not after exposure to DMBA (J:88125)
• tumors develop earlier, proceed at a greater rate and mice develop more tumors (J:88125)

cellular
• MEFs are more resistant to killing after UV-irradiation but not after DMBA exposure (J:88125)
• MEFs are more resistant to killing after UV-irradiation but not after DMBA exposure (J:88125)

growth/size/body
• 8 weeks after birth, homozygotes are somewhat smaller (J:88125)
• 8 weeks after birth, homozygotes are somewhat smaller (J:88125)

integument
• increased incidence of skin tumors after UV-irradiation (J:88125)
• increased incidence of skin tumors after UV-irradiation (J:88125)

Mouse Models of Human Disease
OMIM ID Ref(s)
Xeroderma Pigmentosum, Complementation Group E 278740 J:88125


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory