Mouse Genome Informatics
hm
    Ddb2tm1Linn/Ddb2tm1Linn
involves: 129S/SvEv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Tumorigenesis analysis and Hisptopathological images

tumorigenesis
• skin tumorigenesis is enhanced after exposure to UV light but not after exposure to DMBA
• tumors develop earlier, proceed at a greater rate and mice develop more tumors

cellular
• MEFs are more resistant to killing after UV-irradiation but not after DMBA exposure

growth/size
• 8 weeks after birth, homozygotes are somewhat smaller

integument
• increased incidence of skin tumors after UV-irradiation

Mouse Models of Human Disease
OMIM IDRef(s)
Xeroderma Pigmentosum, Complementation Group E 278740 J:88125