Phenotypes Associated with This Genotype

Genotype
MGI:3036178

• Allelic Composition: Tnfrsf8^tm1Mak/Tnfrsf8^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged thymus ( J:62854 )

increased thymocyte number ( J:62854 )

• double-positive thymocytes less susceptible to anti-CD3-mediated apoptosis

immune system

immune system phenotype ( J:62854 )

N • normal absolute numbers of cells in spleen, lymph node, and bone marrow

N • no developmental abnormalities in T or B cell lineages

N • no overt histological changes in spleen and lymph nodes

N • normal T cell proliferation in response to anti-CD3 Ab, phorbol myristate acetate-calcium ionophore, and staphylococcal enterotoxin B

N • normal apoptotic T cell death in in vitro assays activation assays or after in vivo stimulation with staphylococcal enterotoxin B

N • normal CD8+ cytotoxic T cell memory in vitro and in vivo

N • normal basal serum levels of IgM, IgG1, IgG2a, IgG2b, IgG3

N • normal humoral immune response, both T-dependent and T-independent

enlarged thymus ( J:62854 )

increased thymocyte number ( J:62854 )

• double-positive thymocytes less susceptible to anti-CD3-mediated apoptosis

endocrine/exocrine glands

enlarged thymus ( J:62854 )

increased thymocyte number ( J:62854 )

• double-positive thymocytes less susceptible to anti-CD3-mediated apoptosis