Phenotypes Associated with This Genotype

Genotype
MGI:3034091

• Allelic Composition: Tnfrsf4^tm1Nik/Tnfrsf4^tm1Nik
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:58979 )

N • primary and secondary lymphoid tissues had normal cellularity, expression of lymphocyte differentiation markers, and presence of germinal centers

N • normal response to infection by: Leishmania major, Nippostrongylus brasiliensis, and Theiler's murine encephalomyelitis

N • normal antibody response to various antigens

N • normal response in delayed-type hypersensitivity reactions using oxazolone

decreased T cell proliferation ( J:58979 , J:64552 )

• in response to anti-CD3 epsilon antibodies, but not in mixed lymphocyte reactions, peptide specific response, or stimulation with staphylococcal enterotoxin B (J:58979)

• in response to anti-CD3 epsilon antibodies over the course of 5 days (J:64552)

• corresponding decline in T cell survival over this time (J:64552)

• declines in IL2 production corresponded to declines in proliferation and survival (J:64552)

abnormal CD4-positive, alpha-beta T cell physiology ( J:64552 )

• primary and memory responses impaired in response to keyhole limpet hemocyanin immunization: decreased production of antigen-specific CD4+ cells and memory cells and decreased proliferation, decreased production of cytokines (IL2, IFN-gamma, IL5, IL4), at both 7 days and 35 days post-immunization

abnormal T-helper 2 physiology ( J:68588 )

• impaired ability to mount Th2 response in ovalbumin model of asthma, characterized by lack of production of: IL5, IL4, IgE

decreased susceptibility to type I hypersensitivity reaction ( J:68588 )

• in response to ovalbumin model of asthma, characterized by decreased lung inflammation, especially with lack of eosinophilia, decreased mucus production, decreased goblet cell hyperplasia and decreased airway hyperreactivity

hematopoietic system

decreased T cell proliferation ( J:58979 , J:64552 )

• in response to anti-CD3 epsilon antibodies, but not in mixed lymphocyte reactions, peptide specific response, or stimulation with staphylococcal enterotoxin B (J:58979)

• in response to anti-CD3 epsilon antibodies over the course of 5 days (J:64552)

• corresponding decline in T cell survival over this time (J:64552)

• declines in IL2 production corresponded to declines in proliferation and survival (J:64552)

abnormal CD4-positive, alpha-beta T cell physiology ( J:64552 )

• primary and memory responses impaired in response to keyhole limpet hemocyanin immunization: decreased production of antigen-specific CD4+ cells and memory cells and decreased proliferation, decreased production of cytokines (IL2, IFN-gamma, IL5, IL4), at both 7 days and 35 days post-immunization

abnormal T-helper 2 physiology ( J:68588 )

• impaired ability to mount Th2 response in ovalbumin model of asthma, characterized by lack of production of: IL5, IL4, IgE

cellular

decreased T cell proliferation ( J:58979 , J:64552 )

• in response to anti-CD3 epsilon antibodies, but not in mixed lymphocyte reactions, peptide specific response, or stimulation with staphylococcal enterotoxin B (J:58979)

• in response to anti-CD3 epsilon antibodies over the course of 5 days (J:64552)

• corresponding decline in T cell survival over this time (J:64552)

• declines in IL2 production corresponded to declines in proliferation and survival (J:64552)