Phenotypes Associated with This Genotype

Genotype
MGI:3034051

• Allelic Composition: Dffa^tm1Mxu/Dffa^tm1Mxu
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal apoptosis ( J:50707 , J:88144 )

• induction of apoptosis in bone marrow granulocytes by cyclohexamine is reduced (J:50707)

• DNA condensation in splenocytes and thymocytes is severely impaired (J:50707)

• reduced apoptosis of splenocytes and thymocytes after treatment with apoptotic stimuli (J:88144)

• DNA fragmentation was essentially eliminated in splenocytes and thymocytes after treatment with various apoptotic stimuli (J:88144)

decreased susceptibility to neuronal excitotoxicity ( J:114416 )

• less neuronal cell loss in CA3 as a result of kainic acid injection, fewer mice with lesions and smaller lesions

behavior/neurological

abnormal spatial learning ( J:76476 )

• improved performance in the hidden-platform version of the Morris water maze

• learning occurs more quickly

• better performance than controls in probe-trial tests

nervous system

decreased susceptibility to neuronal excitotoxicity ( J:114416 )

• less neuronal cell loss in CA3 as a result of kainic acid injection, fewer mice with lesions and smaller lesions

abnormal dentate gyrus morphology ( J:76476 )

• higher mean granule cell density in the dentate region of the hippocampus whereas cell densities are normal in CA3 and CA1

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:114416 )

• less neuronal cell loss in CA3 as a result of kainic acid injection, fewer mice with lesions and smaller lesions