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Phenotypes Associated with This Genotype
Genotype
MGI:3033965
Allelic
Composition
Hsf1tm1Miv/Hsf1tm1Miv
Hsf2tm1Miv/Hsf2tm1Miv
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Miv mutation (0 available); any Hsf1 mutation (23 available)
Hsf2tm1Miv mutation (0 available); any Hsf2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Testes are smaller in Hsf2tm1Miv/Hsf2tm1Miv and Hsf1tm1Miv/Hsf1tm1Miv Hsf2tm1Miv/Hsf2tm1Miv mice

cellular
• total lack of sperm in seminal fluid
• the most advanced germ cells present are spermatogonia and pachytene spermatocytes indicating male meiosis does not progress beyond prophase I

mortality/aging
• reduced numbers of double homozygotes are born

endocrine/exocrine glands
• large vacuolated structures and large multinucleated giant cells found in tubules
• large numbers of apoptotic cells in tubules of testes
• less than 50% of wild-type

growth/size/body
• reduced by about 20% compared to wild-type
• reduced by about 20% compared to wild-type

reproductive system
• large vacuolated structures and large multinucleated giant cells found in tubules
• large numbers of apoptotic cells in tubules of testes
• less than 50% of wild-type
• total lack of sperm in seminal fluid
• the most advanced germ cells present are spermatogonia and pachytene spermatocytes indicating male meiosis does not progress beyond prophase I


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory