Phenotypes Associated with This Genotype

Genotype
MGI:3033749

• Allelic Composition: Pparg^tm2Rev/Pparg^tm2Rev; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal white adipose tissue amount ( J:88210 )

• cell loss greater than 80%

abnormal brown adipose tissue morphology ( J:88210 )

• vacuole form sometimes like white adipose cells rather than typical brown fat cells

decreased brown adipose tissue amount ( J:88210 )

• brown adipose tissue mass reduced more than 70% by 6 months of age

decreased brown fat cell number ( J:88210 )

• cell numbers reduced more than 95%

abnormal brown fat cell size ( J:88210 )

increased brown fat cell size ( J:88210 )

• cells are larger and variable in size

increased white fat cell size ( J:88210 )

• more than 50% of white adipocytes are highly hypertrophic

decreased interscapular fat pad weight ( J:88210 )

• diminution of interscapular fat pads detectable by 4-6 weeks

growth/size/body

slow postnatal weight gain ( J:88210 )

• weight gain on a high fat diet is decreased

enlarged liver ( J:88210 )

• hepatomegaly eventually develops as well

homeostasis/metabolism

increased circulating insulin level ( J:88210 )

• insulin levels are increased

insulin resistance ( J:88210 )

• insulin became less efficient at suppressing glucose production

liver/biliary system

enlarged liver ( J:88210 )

• hepatomegaly eventually develops as well

hepatic steatosis ( J:88210 )

• livers were beginning to be steatotic at 6 months of age