Analysis Tools
neoplasm
growth/size/body
 N |
• body weight equivalent to control mice at same age
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reproductive system
|
N |
• histologically normal ovaries
• number of healthy and atretic follicles equivalent to those in control mice
• serum estradiol concentrations equivalent to control mice
• ovary weight equivalent to control mice
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• exhibit a significantly greater number of endometrial glands at P15 and P20; however, by P25, the number of glands is similar to wild-type, indicating accelerated endometrial gland formation
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• accelerated endometrial gland formation during early postnatal uterine development
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• mice that displayed normal estrus had uteri weighing significantly more than wild-type controls during estrus
(J:64154)
• exhibit an increase in uterine wet weight at P5, P10 and P25
(J:96729)
|
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• decreased length of estrus period or failure to display estrus
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absent estrus
(
J:64154
)
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short estrus
(
J:64154
)
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• longer periods of proestrus
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• less than 50% exhibited normal estrus cycle
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• ~50% achieved pregnancy vs. 78% in wild-type controls
• those that did become pregnant produced fewer litters over a 12-month period than wild-type controls
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• when litters were produced, fewer pups per litter were born
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cardiovascular system
|
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• homozygotes form significantly larger aneurysms than wild-type after elastase infusion to induce aneurysm formation (to model abdominal aortic aneurysm)
(J:101938)
• homozygotes, unlike wild-type, also develop aneurysms following saline injection
(J:101938)
• homozygotes show increased and continued progression of aneurysm formation compared with wild-type in a thoracic aortic aneurysm model (induced by calcium chloride treatment)
(J:102182)
|
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• increased left ventricle end-diastolic pressure and volume vs. wild-type controls
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• exhibit accelerated myocardial remodeling after myocardial infarction (coronary ligation) as indicated by increased left ventricular (LV) dilatation and LV dysfunction
the accelerated remodeling can be rescued by MMP inhibition
|
immune system
|
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• bacterial clearance following corneal infection is increased with 2 to 3 orders of magnitude fewer viable bacteria being found in mutant eyes 24 - 48 hours after infection
|
hematopoietic system
|
N |
• normal blood cell counts and subtype distribution
|
|
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• bone marrow cellularity is decreased by approximately 50% without changes in subtype composition
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homeostasis/metabolism
|
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• exhibit accelerated myocardial remodeling after myocardial infarction (coronary ligation) as indicated by increased left ventricular (LV) dilatation and LV dysfunction
the accelerated remodeling can be rescued by MMP inhibition
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• during estrus and diestrus
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• during estrus only
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endocrine/exocrine glands
|
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• exhibit a significantly greater number of endometrial glands at P15 and P20; however, by P25, the number of glands is similar to wild-type, indicating accelerated endometrial gland formation
|
