Phenotypes Associated with This Genotype

Genotype
MGI:3033403

• Allelic Composition: Bub1b^{Gt(neo-btk)1Dai}/Bub1b⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:88223 )

N • in contrast to homozygotes, heterozygous blastocysts developed normally

hematopoietic system

abnormal megakaryocyte differentiation ( J:88223 )

• increased number of megakaryocytes

• defect in the formation of proplatelet-producing megakaryocytes

• no significant increase in the number of platelets in the peripheral blood

enlarged spleen ( J:88223 )

• due to increase in the number of splenic megakaryocytes

abnormal definitive hematopoiesis ( J:88223 )

absent common myeloid progenitor cells ( J:88223 )

• the number of megakaryocytic progenitors was not decreased, but rather increased

• decreased number of erythroid progenitors

decreased erythrocyte cell number ( J:88223 )

immune system

enlarged spleen ( J:88223 )

• due to increase in the number of splenic megakaryocytes

cellular

abnormal megakaryocyte differentiation ( J:88223 )

• increased number of megakaryocytes

• defect in the formation of proplatelet-producing megakaryocytes

• no significant increase in the number of platelets in the peripheral blood

growth/size/body

enlarged spleen ( J:88223 )

• due to increase in the number of splenic megakaryocytes