Analysis Tools
mortality/aging
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• only about 50% survive until after 6 weeks of age
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behavior/neurological
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• subconvulsive doses of pentylenetetrazole (PTZ) lead to high voltage sharp wave bursts
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• explosive running followed by maintained opisthotonus and straub tail
• death usually followed within a few minutes of seizure
• survivors of a seizure resumed normal behavior but developed additional seizures later leading to death
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growth/size/body
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• although body weight was normal at birth, homozygous mice gained weight more slowly after birth
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nervous system
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• subconvulsive doses of pentylenetetrazole (PTZ) lead to high voltage sharp wave bursts
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• explosive running followed by maintained opisthotonus and straub tail
• death usually followed within a few minutes of seizure
• survivors of a seizure resumed normal behavior but developed additional seizures later leading to death
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• 68% more brain edemas resulting from cold injury and size of edemas are much larger
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• selective neuronal degeneration in the hippocampal CA1 in mice aged 4-8 weeks
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• neuronal loss in the pyramidal layer of CA1 24 hours after brief (5 min) hippocampal ischemia leading to a build up of glutamate concentration
• by 4 days after ischemia, neuronal loss is seen throughout CA1 and CA3
• longer periods of ischemia are as damaging to wild-type mice as to homozygous mutants
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homeostasis/metabolism
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• 68% more brain edemas resulting from cold injury and size of edemas are much larger
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