Mouse Genome Informatics
hm
    Cpefat/Cpefat
BKSChpLt.HRS-Cpefat/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
adipose tissue
• noted in all adipose tissue of the body

digestive/alimentary system
• reduced gastric acid secretion and challenged gastrin release

endocrine/exocrine glands
• the presence of immature secretory granules was noted
• some degranulation of beta cells was noted
• hypertrophy and hyperplasia of islets noted

growth/size
• abnormal amounts of fat by 4-5 weeks of age; progressive with age; homozygotes weigh up to 60-70 grams by 6-8 months of age

homeostasis/metabolism
• homozygous mice cannot maintain the core body temperature upon exposure to cold temperature
• transient hyperglycemia noted in males at 7-8 weeks of age
• does not progress to severe diabetes
• increased by 50% over controls (J:18161)
• noted on a high fat diet compared to controls (J:19043)
• increased 2 fold over controls (J:18161)
• noted on a high fat diet compared to controls (J:19043)
• noted on a high fat diet compared to controls
• noted on a high fat diet compared to controls
• noted on a high fat diet compared to controls
• thyrotropin-releasing hormone (TRH) is reduced in the hypothalamus by at least 75% compared to wild-type
• pro-thyrotropin-releasing hormone forms are increased due to impaired processing in the hypothalamus
• cold exposure depresses hypothalamic TRH levels even further, by about 38% compared to 13% in wild-type
• serum gastrin levels are lower than in wild-type after famotidine treatment to inhibit gastric acid secretion
• severe at weaning age (J:10872)
• hyperproinsulinemia was noted; a defect in hormone processing was demonstrated in vitro (J:24436)
• due to poor processing of pro-opiomalanocortin
• circulating T3 levels are significantly higher
• thyroid-stimulating hormone (TSH) concentrations are normal
• 24-fold increase in unprocessed pro-opiomelanocortin levels in the pituitary; poor processing to adrenocorticotropin and unregulated secretion of the unprocessed hormone
• unregulated secretion of unprocessed pro-opiomelanocortin (J:38227)
• pro-opiomalanocortin is constitutively secreted from the anterior pituitary resulting in elevated levels in the circulation (J:40372)
• growth hormone is elevated in the anterior pituitary
• growth hormone is constitutively secreted from the anterior pituitary

reproductive system
• noted in older obese mice; homozygous mice can produce litters if mated before the onset of obesity

nervous system
• deficient processing and unregulated secretion of pro-thyrotrophin releasing hormone

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:10872