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Phenotypes Associated with This Genotype
Genotype
MGI:3033164
Allelic
Composition
Cpefat/Cpefat
Genetic
Background
HRS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpefat mutation (2 available); any Cpe mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• noted in all adipose tissue of the body

endocrine/exocrine glands
• some degranulation of beta cells was noted
• increased numbers of islets noted
• hypertrophy and hyperplasia of islets noted

growth/size/body
• abnormal amounts of fat by 4-5 weeks of age; progressive with age; homozygotes weigh up to 60-70 grams by 6-8 months of age (J:13651)

homeostasis/metabolism
• fluctuations in blood sugar concentrations occur; concentrations of less than 100mg/100ml are common in animals older than 6 months
• transient hyperglycemia noted in males at 7-8 weeks of age
• severe at weaning age (J:10872)

reproductive system
• noted in older mice; mice are not sterile; homozygous mice can produce litters if mated before the onset of obesity

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:10872 , J:13651


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory