Mouse Genome Informatics
hm
    Cpefat/Cpefat
HRS/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
adipose tissue
• noted in all adipose tissue of the body

endocrine/exocrine glands
• some degranulation of beta cells was noted
• increased numbers of islets noted
• hypertrophy and hyperplasia of islets noted

growth/size/body
• noted in all adipose tissue of the body
• abnormal amounts of fat by 4-5 weeks of age; progressive with age; homozygotes weigh up to 60-70 grams by 6-8 months of age (J:13651)

homeostasis/metabolism
• fluctuations in blood sugar concentrations occur; concentrations of less than 100mg/100ml are common in animals older than 6 months
• transient hyperglycemia noted in males at 7-8 weeks of age
• severe at weaning age (J:10872)

reproductive system
• noted in older mice; mice are not sterile; homozygous mice can produce litters if mated before the onset of obesity

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:10872 , J:13651