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Phenotypes Associated with This Genotype
Genotype
MGI:3032571
Allelic
Composition
Tgcog/Tgcog
Genetic
Background
involves: AKR/J * C57BL/6By
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgcog mutation (2 available); any Tg mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• hypertrophy of thyrofollicular cells (J:8567)
• hypertrophy of thyrofollicular cells (J:8567)

growth/size/body
• evident at day 15 postnatal (J:3079)
• evident at day 15 postnatal (J:3079)
• evident by 15 days postnatal (J:8567)
• repaired when diet at weaning was supplemented with desiccated thyroid powder (J:8567)
• evident by 15 days postnatal (J:8567)
• repaired when diet at weaning was supplemented with desiccated thyroid powder (J:8567)

hematopoietic system

homeostasis/metabolism

nervous system
• cerebrum and cerebellum weighed significantly less than littermate controls (J:3079)
• brain stem weight equivalent to littermate controls (J:3079)
• cerebrum and cerebellum weighed significantly less than littermate controls (J:3079)
• brain stem weight equivalent to littermate controls (J:3079)
• hypomyelination, restricted to cerebrum (J:3079)
• hypomyelination, restricted to cerebrum (J:3079)

Mouse Models of Human Disease
OMIM ID Ref(s)
Thyroid Dyshormonogenesis 3; TDH3 274700 J:8567


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory