Phenotypes for Tcf7l2 MGI:3032499 MGI Mouse

mortality/aging

neonatal lethality, complete penetrance ( J:48968 )

• pups die within 24 hours of birth

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:48968 )

• at E16.5 there are no cycling cells detected in intestinal epithelium

abnormal enterocyte morphology ( J:48968 )

• cells of intervillus region do not have characteristics of intervillus prospective crypt cells, instead displaying characteristics including closely packed long microvilli, round nuclei, supranuclear Golgi, many rod-shaped mitochondria, and absence of mitotic figures

decreased enterocyte cell number ( J:48968 )

• enterocytes on villi are decreased in number and broader in homozygotes than in wild-type

endocrine/exocrine glands

enlarged adenohypophysis ( J:86317 )

• anterior pituitary lobes are enlarged to nearly twice the normal height by E14.5

enlarged pituitary gland ( J:86317 )

• a 3-fold increase in combined volume of anterior and intermediate lobes is observed compared to wild-type mice

abnormal pituitary intermediate lobe morphology ( J:86317 )

• prospective intermediate lobe and infundibulum are displaced dorsally; these protrude into space normally occupied by hypothalamus

craniofacial

abnormal craniofacial development ( J:86317 )

• pituitary gland is expanded ventrally between edges of cartilage plate in the midline during palate development

cellular

cellular phenotype ( J:98680 )

N	• no differences in cell proliferation in tissue of small intestine is observed at E14.5

nervous system