Phenotypes Associated with This Genotype

Genotype
MGI:3029930

• Allelic Composition: Kit^W-sh/Kit^W-sh
• Genetic Background: involves: 101/H * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased mast cell degranulation ( J:157470 )

• following chloroquine treatment

decreased mast cell number ( J:145444 )

• mice are described as being mast cell deficient

increased susceptibility to parasitic infection ( J:163761 )

• after second infestation to ticks, mice fail to exhibit resistance (repletion) unlike similarly treated wild-type mice

• however, transfer of wild-type bone marrow restores repletion

pigmentation

abnormal coat/hair pigmentation ( J:6857 )

• the coat is white except for small patches on or near the ears and, infrequently, at the base of the tail

behavior/neurological

impaired behavioral response to xenobiotic ( J:157470 )

• mice exhibit reduced chloroquine-induced scratching compared with similarly treated wild-type mice

hematopoietic system

decreased mast cell degranulation ( J:157470 )

• following chloroquine treatment

abnormal definitive hematopoiesis ( J:6857 )

abnormal erythrocyte cell number ( J:6857 )

decreased erythrocyte cell number ( J:6857 )

• on this background,lower than normal mean hematocrit values were found but did not manifest as an anemia

decreased mast cell number ( J:145444 )

• mice are described as being mast cell deficient

integument

abnormal coat/hair pigmentation ( J:6857 )

• the coat is white except for small patches on or near the ears and, infrequently, at the base of the tail

cellular

decreased mast cell degranulation ( J:157470 )

• following chloroquine treatment