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Phenotypes Associated with This Genotype
Genotype
MGI:3029765
Allelic
Composition
Fhittm1Hbn/Fhit+
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhittm1Hbn mutation (0 available); any Fhit mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 26% of heterozygous mice were found dead before normal life span with evidence of widespread infections

neoplasm
• in untreated mice, the incidence of spontaneous tumors of various types was 53%
• 10 weeks after NMBA treatment, all heterozygous mice exhibited tumors in various tissues, especially the gastrointestinal tract including the forestomach and squamocolumnar juction; the incidence of tumors in control mice was 25% (J:61946)
• 78% of mice exhibit large sebaceous tumors after a single dose of NMBA, especially in the gastrointestinal tract (J:71303)
• mutants develop preneoplastic lesions of the uterus more frequently than wild-type after multiple doses of benzol[a]pyrene (B[a]P), however develop similar levels of forestomach and lung tumors (J:110096)

hematopoietic system
• granulocyte numbers are 2-6% of total blood lymphocytes; controls granulocyte numbers are 15% of total

immune system
• granulocyte numbers are 2-6% of total blood lymphocytes; controls granulocyte numbers are 15% of total
• mice exhibit evidence of widespread infections and abcesses

homeostasis/metabolism
• 10 weeks after NMBA treatment, all heterozygous mice exhibited tumors in various tissues, especially the gastrointestinal tract including the forestomach and squamocolumnar juction; the incidence of tumors in control mice was 25% (J:61946)
• 78% of mice exhibit large sebaceous tumors after a single dose of NMBA, especially in the gastrointestinal tract (J:71303)
• mutants develop preneoplastic lesions of the uterus more frequently than wild-type after multiple doses of benzol[a]pyrene (B[a]P), however develop similar levels of forestomach and lung tumors (J:110096)

integument
• spontaneous alopecia areata and hair bulb cell apoptosis are greatly accelerated in mutants compared to wild-type

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Muir-Torre syndrome DOID:0050465 OMIM:158320
J:61946


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory