Phenotypes Associated with This Genotype

Genotype
MGI:3029737

• Allelic Composition: Rgma^tm1Arbr/Rgma^tm1Arbr
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:87768 )

• fewer mice were born than expected by the Mendelian ratio

craniofacial

abnormal cranium morphology ( J:87768 )

• incomplete penetrance; observed in ~50% of fetuses at E16.5

• these mice exhibited exencephaly

embryo

abnormal embryo development ( J:87768 )

incomplete rostral neuropore closure ( J:87768 )

• incomplete penetrance; observed in ~50% of fetuses at E10.5

skeleton

abnormal cranium morphology ( J:87768 )

• incomplete penetrance; observed in ~50% of fetuses at E16.5

• these mice exhibited exencephaly

nervous system

nervous system phenotype ( J:87768 )

N • normal mapping of retinal ganglion cell axons in the visual system

incomplete rostral neuropore closure ( J:87768 )

• incomplete penetrance; observed in ~50% of fetuses at E10.5

abnormal brain development ( J:87768 )

• major morphological defects of the dorsal brain structures were observed in exencephalic mice

• normal ventral brain, brainstem, and spinal cord morphology

exencephaly ( J:87768 )

• incomplete penetrance; observed in ~50% of fetuses

• these mice lacked cranial skull tissue