Mouse Genome Informatics
hm
    Foxl2tm1Tre/Foxl2tm1Tre
involves: 129P2/OlaHsd * Black Swiss * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• although homozygotes are born at the expected ratio, 95% die before weaning
• remaining animals live up to one year

reproductive system
N
• surviving males are fully fertile (J:87737)
• by 16 weeks ovaries are devoid of healthy follicles and oocytes (J:87737)
• at 2 weeks of age, reduced numbers of follicles (J:87737)
• follicles with less than 2 granulosa cell layers (J:87737)
• granulose cells do not complete squamous to cuboidal transition (J:87737)
• oocytes in follicles undergoing atresia (J:87737)
• by 8 weeks, no quiescent primordial follicles left (J:87737)
• increased zona pellucida reminants found (J:87737)
• no signs of granulose proliferation (J:87737)
• all follicles have undergone mutant development (J:87737)
• by 16 weeks, ovaries are approximately 1/20 normal size (J:87737)

endocrine/exocrine glands
• by 16 weeks ovaries are devoid of healthy follicles and oocytes (J:87737)
• at 2 weeks of age, reduced numbers of follicles (J:87737)
• follicles with less than 2 granulosa cell layers (J:87737)
• granulose cells do not complete squamous to cuboidal transition (J:87737)
• oocytes in follicles undergoing atresia (J:87737)
• by 8 weeks, no quiescent primordial follicles left (J:87737)
• increased zona pellucida reminants found (J:87737)
• no signs of granulose proliferation (J:87737)
• all follicles have undergone mutant development (J:87737)
• by 16 weeks, ovaries are approximately 1/20 normal size (J:87737)

Mouse Models of Human Disease
OMIM IDRef(s)
Blepharophimosis, Ptosis, and Epicanthus Inversus; BPES 110100 J:87737