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Phenotypes Associated with This Genotype
Genotype
MGI:3029674
Allelic
Composition
Foxl2tm1Tre/Foxl2tm1Tre
Genetic
Background
involves: 129P2/OlaHsd * Black Swiss * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxl2tm1Tre mutation (0 available); any Foxl2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although homozygotes are born at the expected ratio, 95% die before weaning
• remaining animals live up to one year

reproductive system
N
• surviving males are fully fertile
• by 16 weeks ovaries are devoid of healthy follicles and oocytes
• at 2 weeks of age, reduced numbers of follicles
• follicles with less than 2 granulosa cell layers
• granulose cells do not complete squamous to cuboidal transition
• oocytes in follicles undergoing atresia
• by 8 weeks, no quiescent primordial follicles left
• increased zona pellucida reminants found
• no signs of granulose proliferation
• all follicles have undergone mutant development
• by 16 weeks, ovaries are approximately 1/20 normal size

endocrine/exocrine glands
• by 16 weeks ovaries are devoid of healthy follicles and oocytes
• at 2 weeks of age, reduced numbers of follicles
• follicles with less than 2 granulosa cell layers
• granulose cells do not complete squamous to cuboidal transition
• oocytes in follicles undergoing atresia
• by 8 weeks, no quiescent primordial follicles left
• increased zona pellucida reminants found
• no signs of granulose proliferation
• all follicles have undergone mutant development
• by 16 weeks, ovaries are approximately 1/20 normal size

Mouse Models of Human Disease
OMIM ID Ref(s)
Blepharophimosis, Ptosis, and Epicanthus Inversus; BPES 110100 J:87737


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory