Mouse Genome Informatics
hm
    Foxl2tm1Tre/Foxl2tm1Tre
involves: 129P2/OlaHsd * Black Swiss * CD-1
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although homozygotes are born at the expected ratio, 95% die before weaning
• remaining animals live up to one year

reproductive system
N
• surviving males are fully fertile
• by 16 weeks ovaries are devoid of healthy follicles and oocytes
• at 2 weeks of age, reduced numbers of follicles
• follicles with less than 2 granulosa cell layers
• granulose cells do not complete squamous to cuboidal transition
• oocytes in follicles undergoing atresia
• by 8 weeks, no quiescent primordial follicles left
• increased zona pellucida reminants found
• no signs of granulose proliferation
• all follicles have undergone mutant development
• by 16 weeks, ovaries are approximately 1/20 normal size

endocrine/exocrine glands
• by 16 weeks ovaries are devoid of healthy follicles and oocytes
• at 2 weeks of age, reduced numbers of follicles
• follicles with less than 2 granulosa cell layers
• granulose cells do not complete squamous to cuboidal transition
• oocytes in follicles undergoing atresia
• by 8 weeks, no quiescent primordial follicles left
• increased zona pellucida reminants found
• no signs of granulose proliferation
• all follicles have undergone mutant development
• by 16 weeks, ovaries are approximately 1/20 normal size

Mouse Models of Human Disease
OMIM IDRef(s)
Blepharophimosis, Ptosis, and Epicanthus Inversus; BPES 110100 J:87737