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Phenotypes Associated with This Genotype
Genotype
MGI:3029479
Allelic
Composition		 Stamtm2Sug/Stamtm2Sug
Stam2tm1Sug/Stam2tm1Sug
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stam2tm1Sug mutation (2 available); any Stam2 mutation (57 available)
Stamtm2Sug mutation (1 available); any Stam mutation (45 available)
Tg(Lck-cre)I57Jxm mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell proliferation ( J:80617 )
• responses to TCR stimulation and cytokines are severely impaired
decreased T cell number ( J:80617 )
• numbers of mature single positive CD4 or CD8 cells were reduced, and peripheral T cell numbers were reduced

immune system
decreased T cell proliferation ( J:80617 )
• responses to TCR stimulation and cytokines are severely impaired
decreased T cell number ( J:80617 )
• numbers of mature single positive CD4 or CD8 cells were reduced, and peripheral T cell numbers were reduced

cellular
decreased T cell proliferation ( J:80617 )
• responses to TCR stimulation and cytokines are severely impaired

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory