Mouse Genome Informatics
tg
    Tg(APPSWE)2576Kha/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
other phenotype
• increase in insoluble amyloid beta and plaques with aging; greater increase in plaques in females than males (J:76863)

behavior/neurological
N
• 12 month old mice exhibit normal motor coordination on the rotarod (J:180385)
• spend more time in the open arms of an elevated plus maze
• mutants exhibit impaired long-trace interval eyeblink conditioning at 6 months of age
• however, mutants do not exhibit impaired delay eyeblink conditioning even at 12 months of age, although it is slightly but insignificantly decreased
• impaired spatial learning in a morris water maze
• in a probe trial mice fail to occupy the target quadrant longer than chance indicating memory retention deficits

homeostasis/metabolism
• females exhibit an increase in levels of synaptic zinc with aging

nervous system
• increase in insoluble amyloid beta and plaques with aging; greater increase in plaques in females than males (J:76863)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:114480 , J:180385