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Phenotypes Associated with This Genotype
Genotype
MGI:3029285
Allelic
Composition
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSWE)2576Kha mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• 12 month old mice exhibit normal motor coordination on the rotarod
• mutants exhibit impaired long-trace interval eyeblink conditioning at 6 months of age
• however, mutants do not exhibit impaired delay eyeblink conditioning even at 12 months of age, although it is slightly but insignificantly decreased
• impaired spatial learning in a morris water maze
• in a probe trial mice fail to occupy the target quadrant longer than chance indicating memory retention deficits
• spend more time in the open arms of an elevated plus maze

homeostasis/metabolism
• females exhibit an increase in levels of synaptic zinc with aging
• increase in insoluble amyloid beta and plaques with aging; greater increase in plaques in females than males (J:76863)

nervous system
• increase in insoluble amyloid beta and plaques with aging; greater increase in plaques in females than males (J:76863)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:114480 , J:180385


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory