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Phenotypes Associated with This Genotype
Genotype
MGI:3029285
Allelic
Composition
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• 12 month old mice exhibit normal motor coordination on the rotarod
• mutants exhibit impaired long-trace interval eyeblink conditioning at 6 months of age
• however, mutants do not exhibit impaired delay eyeblink conditioning even at 12 months of age, although it is slightly but insignificantly decreased
• impaired spatial learning in a morris water maze
• in a probe trial mice fail to occupy the target quadrant longer than chance indicating memory retention deficits
• spend more time in the open arms of an elevated plus maze

homeostasis/metabolism
• females exhibit an increase in levels of synaptic zinc with aging
• increase in insoluble amyloid beta and plaques with aging; greater increase in plaques in females than males (J:76863)

nervous system
• increase in insoluble amyloid beta and plaques with aging; greater increase in plaques in females than males (J:76863)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:114480 , J:180385


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory