Phenotypes Associated with This Genotype

Genotype
MGI:3029279

• Allelic Composition: Slc30a3^tm1Rpa/Slc30a3^tm1Rpa; Tg(APPSWE)2576Kha/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:76863 )

• plaque formation and insoluble amyloid beta levels are reduced relative to hemizygous Tg(APPSWE)2576HKahs mice that carried two wild copies of Slc30a3

• no sexual difference in synaptic zinc levels, plaque formation, or insoluble amyloid beta levels

• plaques are smaller in size than in single Tg(APPSWE)2576Kha hemizygotes

• mutants exhibit an increased ratio of souluble/insoluble amyloid beta at 18 months of age compared to single Tg(APPSWE)2576Kha hemizygotes

decreased brain zinc level ( J:76863 )

• males and females exhibit a decrease in levels of synaptic and total zinc compared to single Tg(APPSWE)2576Kha hemizygotes

homeostasis/metabolism

amyloid beta deposits ( J:76863 )

• plaque formation and insoluble amyloid beta levels are reduced relative to hemizygous Tg(APPSWE)2576HKahs mice that carried two wild copies of Slc30a3

• no sexual difference in synaptic zinc levels, plaque formation, or insoluble amyloid beta levels

• plaques are smaller in size than in single Tg(APPSWE)2576Kha hemizygotes

• mutants exhibit an increased ratio of souluble/insoluble amyloid beta at 18 months of age compared to single Tg(APPSWE)2576Kha hemizygotes

decreased brain zinc level ( J:76863 )

• males and females exhibit a decrease in levels of synaptic and total zinc compared to single Tg(APPSWE)2576Kha hemizygotes