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Phenotypes Associated with This Genotype
Genotype
MGI:3029267
Allelic
Composition
Tgm2tm1Gml/Tgm2tm1Gml
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgm2tm1Gml mutation (3 available); any Tgm2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• increased death (~60% of treated mice died) after carbon tetrachloride (CCl4) administration (J:82489)
• increased death (~60% of treated mice died) after carbon tetrachloride (CCl4) administration (J:82489)

hematopoietic system
• small, but significant (J:75566)
• small, but significant (J:75566)
• small, but significant (J:75566)
• small, but significant (J:75566)

homeostasis/metabolism
• in fed, but not fasted, state (J:78633)
• in fed, but not fasted, state (J:78633)
• after intraperitoneal glucose administration (J:78633)
• after intraperitoneal glucose administration (J:78633)
• glucose intolerance after intraperitoneal glucose administration (J:78633)
• glucose intolerance after intraperitoneal glucose administration (J:78633)
• greater hypoglyemic response than controls upon intraperitoneal insulin administration (J:78633)
• greater hypoglyemic response than controls upon intraperitoneal insulin administration (J:78633)
• in those that survived, increased hepatic injury after CCl4 administration (J:82489)
• in those that survived, increased hepatic injury after CCl4 administration (J:82489)

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young; MODY 606391 J:75566 , J:78633 , J:82489


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory