Phenotypes Associated with This Genotype

Genotype
MGI:3029261

• Allelic Composition: Stat2^tm1Shnd/Stat2^tm1Shnd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:66564 )

• after a dexamethasone challenge, mutants exhibit a substantial repopulation of the CD4/CD8 double-positive compartment within 2-5 days whereas wild-type mice only show an increase in their CD8+ population

increased susceptibility to Riboviria infection ( J:66564 )

• mutants succumb to vesicular stomatitis virus (VSV) infection with doses that are about 6 logs lower than in controls

• primary embryonic fibroblasts infected with VSV produce about 40 times more virus than wild-type cells

• IFN-alpha treatment afforded no protection against VSV infection as in wild-type

hematopoietic system

abnormal T cell differentiation ( J:66564 )

• after a dexamethasone challenge, mutants exhibit a substantial repopulation of the CD4/CD8 double-positive compartment within 2-5 days whereas wild-type mice only show an increase in their CD8+ population