Phenotypes Associated with This Genotype

Genotype
MGI:3029239

• Allelic Composition: Sox4^tm2Cle/Sox4^tm2Cle
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:32741 )

• homozygous embryos died at E14

cardiovascular system

failure of conotruncal ridge closure ( J:32741 )

• abnormal endocardial ridges; never fused and failed to develop into semiluminar valves

ventricular septal defect ( J:32741 )

• septation defect affected the outlet portion of the ventricles and the great arteries

abnormal semilunar valve morphology ( J:32741 )

• dysplasia of the valves

abnormal blood circulation ( J:32741 )

• oscillating blood flow

increased heart rate ( J:32741 )

hematopoietic system

abnormal B cell differentiation ( J:32741 )

• very few mature B cells are produced in irradiated mice reconstituted with mutant fetal liver cells

decreased pro-B cell number ( J:32741 )

• pro-B cell numbers were reduced

absent pre-B cells ( J:32741 )

• pre-B cells were nearly absent

homeostasis/metabolism

hydrops fetalis ( J:32741 )

• generalized edema apparent at E14

immune system

abnormal B cell differentiation ( J:32741 )

• very few mature B cells are produced in irradiated mice reconstituted with mutant fetal liver cells

decreased pro-B cell number ( J:32741 )

• pro-B cell numbers were reduced

absent pre-B cells ( J:32741 )

• pre-B cells were nearly absent