Phenotypes Associated with This Genotype

Genotype
MGI:3029022

• Allelic Composition: Rhog^tm1Tnr/Rhog^tm1Tnr
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte physiology ( J:87580 )

increased B cell proliferation ( J:87580 )

• respond slightly better to antigen receptor triggered stimulation

increased immunoglobulin level ( J:87580 )

• elevated serum levels of IgG1 and IgG2b while levels of IgM, IgG2a, IgG3, and IgA were normal

• responses to thymus dependent antigens tended to result in higher levels of specific antibodies

abnormal CD4-positive, alpha-beta T cell physiology ( J:87580 )

abnormal T-helper 2 physiology ( J:87580 )

• Il-5 production by Th2 cells decreased

nervous system

nervous system phenotype ( J:87580 )

N • neural organization of the brain was normal

hematopoietic system

abnormal leukocyte physiology ( J:87580 )

increased B cell proliferation ( J:87580 )

• respond slightly better to antigen receptor triggered stimulation

increased immunoglobulin level ( J:87580 )

• elevated serum levels of IgG1 and IgG2b while levels of IgM, IgG2a, IgG3, and IgA were normal

• responses to thymus dependent antigens tended to result in higher levels of specific antibodies

abnormal CD4-positive, alpha-beta T cell physiology ( J:87580 )

abnormal T-helper 2 physiology ( J:87580 )

• Il-5 production by Th2 cells decreased

cellular

increased B cell proliferation ( J:87580 )

• respond slightly better to antigen receptor triggered stimulation