Phenotypes Associated with This Genotype

Genotype
MGI:3028933

• Allelic Composition: Anxa2^tm1Kah/Anxa2^tm1Kah
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vascular development ( J:87621 )

abnormal angiogenesis ( J:87621 )

• defects in fibrin and collagen I matrix remodeling

• neoangiogenesis is inhibited

growth/size/body

decreased body weight ( J:87621 )

• weight was 10-13% below normal by 12 months

hematopoietic system

abnormal hematopoietic system physiology ( J:87621 )

homeostasis/metabolism

abnormal blood coagulation ( J:87621 )

• 1.5-2.9 fold increase in fibrin in lung, spleen, small intestine, liver, heart, and kidney by 2 months

• also microvascular accumulation of fibrin in these tissues

• very little plasmin generation from endothelial cell surfaces

increased susceptibility to induced thrombosis ( J:87621 )

• increased succeptibility to acute carotid artery thrombosis