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Phenotypes Associated with This Genotype
Genotype
MGI:3028691
Allelic
Composition
Ercc4tm1Fwa/Ercc4tm1Fwa
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc4tm1Fwa mutation (0 available); any Ercc4 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die approximately 3 weeks after birth

cellular
• abnormal hepatic cells with enlarged nuclei
• cultured embryonic fibroblasts were hypersensitive to UV irradiation and mitomycin C treatment

growth/size/body
• 73% decrease in body weight relative to wild-type and heterozygous littermates at 15 days of age

liver/biliary system

Mouse Models of Human Disease
OMIM ID Ref(s)
Xeroderma Pigmentosum, Complementation Group F; XPF 278760 J:87684


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory