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Phenotypes Associated with This Genotype
involves: BALB/cAnN * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6batrd1 mutation (2 available); any Pde6b mutation (101 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• pale by 10 weeks of age
• slightly thinner at 3.5 weeks of age followed by rapid progressive thinning over the next 3 weeks
• at 6 weeks of age, 3-4 cell layers are present in the peripheral retina
• slow onset of degeneration; the visual tracking response persists until several weeks of age in contrast to Pde6brd1 homozygous mice (J:75964)
• develops as mice age, onset is later than in Pde6b rd1 (J:101336)
• at 3.5 weeks of age, at least 20% of mice respond to a 2 degree grating and 90% respond to a 4 degree grating in a visual tracking drum assay
• at 6 weeks of age mice respond well to a 4 or 8 degree grating in a visual tracking drum assay
• by 10 weeks of age mice fail to respond in a visual tracking drum assay
• effectively blind by 10 weeks of age

nervous system
• pale by 10 weeks of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.20
The Jackson Laboratory