Phenotypes Associated with This Genotype

Genotype
MGI:3027998

• Allelic Composition: \Fgf3^tm1Sng/\Fgf3^tm1Sng; \Fgf10^tm1Ska/\Fgf10^tm1Ska
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:87221 )

• no double homozygous embryos found after E10

hearing/vestibular/ear

abnormal ear development ( J:87221 )

• severe loss of otic tissue by E8-E10

small otic vesicle ( J:87221 )

• reduced size of otic vesicles and more ventrally located by E9-E10

• extent of effect on otic vesicle was variable

nervous system

absent vestibulocochlear ganglion ( J:87221 )