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Phenotypes Associated with This Genotype
Genotype
MGI:3027982
Allelic
Composition
Slc4a1wan/Slc4a1wan
Genetic
Background
C3H/HeJ-Slc4a1wan/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc4a1wan mutation (1 available); any Slc4a1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals die by 72 hours of age

hematopoietic system
• presence of binucleated erythroblasts at 14% compared to 2% in wild-type
• fetal counts are decreased at E15-E18
• cells have occasional membrane extensions
• reticulocytes are decreased in number by E15 and are absent thereafter

cellular
• presence of binucleated erythroblasts at 14% compared to 2% in wild-type

integument
• animals are noticeably pale at birth

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary spherocytosis type 4 DOID:0110919 OMIM:612653
J:89043


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory