Phenotypes Associated with This Genotype

Genotype
MGI:3027936

• Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:147752 )

♂ • with age, sperm counts in males decrease to about one quarter by 17 weeks

decreased testis weight ( J:147752 )

♂ • from 4 weeks onward, males display decreased testis weight

testicular atrophy ( J:147752 )

♂ • males display increasing testicular atrophy with age

vision/eye

blindness ( J:147752 )

• 3-month old animals are completely blind

cellular

oligozoospermia ( J:147752 )

♂ • with age, sperm counts in males decrease to about one quarter by 17 weeks

endocrine/exocrine glands

decreased testis weight ( J:147752 )

♂ • from 4 weeks onward, males display decreased testis weight

testicular atrophy ( J:147752 )

♂ • males display increasing testicular atrophy with age