Phenotypes Associated with This Genotype

Genotype
MGI:3027900

• Allelic Composition: Spo11^tm1Rdco/Spo11^tm1Rdco
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal reproductive system morphology ( J:65881 )

abnormal female reproductive system morphology ( J:65881 )

♀

abnormal ovary morphology ( J:65881 )

♀ • defects seen in fetal ovaries at E15

abnormal gametogenesis ( J:65881 )

abnormal female meiosis ( J:65881 )

♀ • problems in early stages of meiosis I

abnormal spermatogenesis ( J:65881 )

♂

abnormal male meiosis ( J:194067 )

♂ • male germ cells lack double strand breaks and are defective recombination and synapsis

♂ • preleptotene pairing is impaired

♂ • transgene expression of Spo11alpha does not rescue preleptotene pairing

arrest of male meiosis ( J:65881 )

♂ • meiosis in spermatocytes normal through leptotene stage

♂ • meiosis arrested at zygotene stage

♂ • little or no synapsis (about 5-10% of nuclei)

♂ • synapsis that does occur is between nonhomologous chromosomes

♂ • lack of Rad51 and Dmc1 foci

♂ • no spermatocytes reach pachytene stage

abnormal male reproductive system morphology ( J:65881 )

♂

abnormal seminiferous tubule morphology ( J:65881 )

♂ • many tubules are barren

♂ • about 20% of tubules with clusters of apoptotic cells

small testis ( J:65881 )

♂

abnormal fertility/fecundity ( J:65881 )

female infertility ( J:65881 )

♀

male infertility ( J:65881 )

♂

endocrine/exocrine glands

abnormal ovary morphology ( J:65881 )

♀ • defects seen in fetal ovaries at E15

abnormal seminiferous tubule morphology ( J:65881 )

♂ • many tubules are barren

♂ • about 20% of tubules with clusters of apoptotic cells

small testis ( J:65881 )

♂

cellular

abnormal female meiosis ( J:65881 )

♀ • problems in early stages of meiosis I

abnormal male meiosis ( J:194067 )

♂ • male germ cells lack double strand breaks and are defective recombination and synapsis

♂ • preleptotene pairing is impaired

♂ • transgene expression of Spo11alpha does not rescue preleptotene pairing

arrest of male meiosis ( J:65881 )

♂ • meiosis in spermatocytes normal through leptotene stage

♂ • meiosis arrested at zygotene stage

♂ • little or no synapsis (about 5-10% of nuclei)

♂ • synapsis that does occur is between nonhomologous chromosomes

♂ • lack of Rad51 and Dmc1 foci

♂ • no spermatocytes reach pachytene stage